Goalkeeper Kwame Baah, Habib Mohammed, Emmanuel Keyekeh, Evans Adumako and Abdul Ganiyu will all miss Kotoko’s League match against Bechem United.
The five players have been ruled out of the game due to various injury setbacks.
Coach Mariano Barreto will now have to do with the available materials at his disposal.
The Reds are still keen to leapfrog rivals Hearts of Oak at the top despite 3points separating them.
A win over Bechem United and a slip by Hearts of Oak against Liberty Professionals will keep their title chase alive.
Should they fail to win the title, the Porcupine Warriors will be bent on lifting the FA Cup trophy to make an appearance in CAF’s inter Club competition.